Plaque Meningioma, Sellar Region, Treated with QIAPI 1®, Case Report
Meningiomas, the most common intracranial tumor, though mostly benign, can be recurrent and fatal. Traditionally they have been understudied compared to other central nervous system (CNS) tumors. Lastly, there has been renewed interest in uncovering the molecular topography of these tumors, trying to identify key driver alterations contributing to meningioma development and progression.
Most of these tumors are benign and can be treated with surgery and/or radiotherapy (RT). A significant proportion of meningiomas (20–30%) are clinically aggressive and have a proclivity to recur with significant morbidity and even mortality. Aggressive subtypes often have a 5-year progression free survival (PFS) probability of less than 50%. There is therefore a significant need to develop more treatments for this population, which is bound to continue increasing in size as our population ages.
The role of oxygen in disorderly growing cells has been considered somewhat vague. Since 1924, Otto Warburg reports that most cancer cells produce large amounts of lactate. Subsequent studies showed that mitochondrial function is not impaired in most cancer cells. But with the observation that human eukaryotic cells have molecules capable of dissociating water molecules located inside the same cell, as in plants, then the paradox mentioned above begins to be resolved, because then it turns out that our body does not take oxygen from the air that surrounds it, but produces it by itself, and this inside each cell. And the oxygen that is produced intracellularly is for the cell that produces it to use almost completely.
And when oxygen levels at the intracellular level are inadequate, the highly complex but strictly regulated metabolism’s cells are affected in an unpredictable and generalized way, as evidenced by genomic instability, which is one of the characteristics of the cancer cell.
Therefore, we can infer that the primary origin of the biochemical alterations that lead to uncontrolled cell proliferation is the loss of balance between the generation of oxygen at the intracellular level, from the dissociation of the water molecules contained inside the same cell, and the oxygen (and hydrogen) requirements inside it. And by restoring this balance, which is essential for the origin of life and the normal functioning of cells, tissues, organs, and systems, it is possible for cells to regain their normal and quite complex metabolic activity.
The report of this case of plaque meningioma that improves substantially with the administration of QIAPI 1™, opens new and promising possibilities for the study and treatment of patients affected by abnormal cell proliferation.