Successful Treatment Difficult-to-Treat Pseudomonas aeruginosa Endocarditis Using Cefiderocol: A Case Report
Infectious endocarditis is the inflammation of the endocardium and the cardiac valves. It is primarily a disease caused by bacteria that can lead to rapid and significant morbidity and mortality if not efficiently diagnosed and treated. The current standard of care for treating IE is dependent on identifying the offending microorganism and its susceptibility to antimicrobials, sometimes requiring surgery. Infective endocarditis can pose an even more significant challenge when resistance to multiple antibiotics develops. We present a case of a 47-year-old female with difficult- to-treat Pseudomonas aeruginosa (DTR-PA) mitral and aortic valve infective endocarditis with a myriad of cardiac and extra-cardiac complications, treated with cefiderocol for six weeks. This case illustrates the first documented incidence of treatment efficacy with cefiderocol monotherapy in treating difficult-to-treat pseudomonas aeruginosa infective endocarditis.