Is There a Need for Testosterone Therapy in Older Men?
Purpose: To investigate the potential benefits of testosterone administration to elderly men (>65 years) with late onset hypogonadism (LOH).
Materials and Methods: Literature review is confirming the benefits of testosterone treatment in the long-term.
Results: There was a progressive decrease in body weight and waist circumference. Beneficial effects on lipids and other metabolic factors and on psychological and sexual functioning progressed over the first 24 to 42 months and were sustained. Rather than deterioration, there was an improvement in urinary parameters. Prostate volume and prostate specific antigen increased moderately. Hematocrit levels increased but remained within safe margins.
Conclusions: The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins. Age itself need not be a contraindication to testosterone treatment of elderly men with LOH.